John Mattison practiced multiple specialties as a Physician before dedicating his career to the intersection of emerging technology, clinical practice, and operational excellence. He led the largest digital transformation team and project in the US while at Kaiser Permanente. His world class team finished the project a full year ahead of schedule and $267 million under budget. He is the founder of the XML standard for health record interoperability, known as the Clinical Document Architecture (CDA), served on the board of SNOMED International for six years, and currently chairs the Clinical Workgroup of the Global Alliance for Genomics and Health (GA4GH). He has mentored hundreds of startups, is actively involved in large scale projects involving drones as first responders, AI, machine learning and big data analytics, coordination of social services across a large geographic area, serves on the California Cybersecurity task force, and remains accountable for the designs, deployment, and support of all technology services for the largest region of Kaiser Permanente. He is co-editor of the textbook on Health Information Technology (McGraw Hill, 2018), has written chapters on various topics in multiple books, and has published many articles on a wide range of topics. He teaches at Singularity University in addition to multiple other universities and medical schools, including Physician Leadership Training at UC San Diego. He conducts workshops on health policy, health technology, and innovation across the US and in seven other countries. His goal is to ‘use modern technology to restore ancient wisdom’ by creating a ‘behavioral symphony of wellness”. He focuses on the convergence of multiple exponential technologies to solve pressing issues in healthcare at scale, using the approach of a multi-platform ecosystem, aka “Plecosystem” approach. He has advocated the implementation and use of a “motivational formulary” to help motivate individuals towards their own goals using their personal values as a critical element of personalized medicine.